@article{ref1,
title="Utility of S100b serum level for the determination of concussion in male rugby players",
journal="Sports medicine",
year="2016",
author="Bouvier, Damien and Duret, Thomas and Abbot, Mathieu and Stiernon, Thibault and Pereira, Bruno and Coste, Aurélien and Chazal, Jean and Sapin, Vincent",
volume="47",
number="4",
pages="781-789",
abstract="BACKGROUND: The incidence of concussion in professional direct-contact sports, particularly in rugby, has increased in recent years. To date, cognitive assessment is the most common means of determining whether a concussed player can return to the game. Serum S100B assay, an objective blood test known to be useful in brain injury management, may offer a novel additional approach to the management of concussed male rugby players. <br><br>OBJECTIVE: The aim of this study was to investigate the S100B utility for the determination of concussion in a professional 15-players-a-side rugby team. <br><br>METHODS: Thirty-nine male rugby players were included in a prospective study during the 2014-2015 French championship season. Serum sampling was carried out several times at baseline and after a match and/or a concussion, at set times (2, 36 h). Serum S100B concentrations were determined using chemiluminescence immunoassay on a Roche Diagnostics(®) instrument. <br><br>RESULTS: The players' basal serum S100B was stable during the season and was not correlated with anthropometric data, body composition, or creatine kinase concentration. A significant increase in S100B concentration within 2 h after a game (without concussion) was observed. This increase was correlated with the number of body collisions during a match. Seventy-seven assays were performed 36 h after a game, including the follow-up of five concussed players. Thirty-six hours after a match, an increase of a minimum of 20 % compared with individual basal concentrations identified concussion with 100 % sensitivity and 81 % specificity. <br><br>CONCLUSION: S100B measured 36 h after a match is thus a discriminating test to identify concussion in a male rugby player, with a 100 % negative predictive value.<p /> <p>Language: en</p>",
language="en",
issn="0112-1642",
doi="10.1007/s40279-016-0579-9",
url="http://dx.doi.org/10.1007/s40279-016-0579-9"
}