@article{ref1,
title="CYP2D6 ultra-rapid metabolizer phenotype not associated with attempted suicide in a large sample of psychiatric inpatients",
journal="Pharmacogenomics",
year="2016",
author="Stephens, Dustin B. and De Leon, Jose",
volume="17",
number="12",
pages="1295-1304",
abstract="AIM: Suicide accounts for over 800,000 deaths per year worldwide and is the tenth-leading cause of mortality in USA. Several studies have investigated cytochrome P450 CYP2D6 ultra-rapid metabolizer (UM) phenotype in relation to suicidality, with mixed results. This study tested the hypothesis of increased suicide risk among CYP2D6 UMs. PATIENTS & METHODS: Among the 4264 state psychiatric hospital inpatients included, 2435 (57%) reported a prior suicide attempt. <br><br>RESULTS: No association between UM status and attempted suicide was observed in bivariate (odds ratio: 0.87; 95% CI: 0.53-1.25), multivariate (adjusted odds ratio: 0.89; 95% CI: 0.55-1.46), or risk-stratified analyses. <br><br>CONCLUSION: These results contrast with prior reports of increased suicidality among CYP2D6 UMs and highlight the pressing need to identify reliable screening methods to better address this persistent public health problem.<p /> <p>Language: en</p>",
language="en",
issn="1462-2416",
doi="10.2217/pgs-2016-0086",
url="http://dx.doi.org/10.2217/pgs-2016-0086"
}