@article{ref1,
title="Suicidal behaviour in youths with depression treated with new-generation antidepressants: Meta-analysis",
journal="British journal of psychiatry",
year="2006",
author="Dubicka, B. and Hadley, S. and Roberts, C.",
volume="189",
number="5",
pages="393-398",
abstract="BACKGROUND: Concern exists that antidepressants can cause suicidality in youths with depression. AIMS: To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants. METHOD: A meta-analysis was carried out to calculate odds ratios for the combined data. RESULTS: Self-harm or suicide-related events occurred in 71 of 1487 (4.8%) of depressed youths treated with antidepressants v. 38 of 1254 (3.0%) of those given placebo (fixed effects odds ratio 1.70, 95% CI 1.13-2.54, P=0.01). There was a trend for individual suicidal thoughts, attempts and self-harm to occur more often in youths taking antidepressants than in those given placebo, but none of these differences was statistically significant. CONCLUSIONS: Antidepressants may cause a small short-term risk of self-harm or suicidal events in children and adolescents with major depressive disorder.<p /> <p>Language: en</p>",
language="en",
issn="0007-1250",
doi="10.1192/bjp.bp.105.011833",
url="http://dx.doi.org/10.1192/bjp.bp.105.011833"
}