@article{ref1,
title="Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion",
journal="Journal of psychiatry and neuroscience",
year="2007",
author="Leyton, Marco and aan het Rot, Marije and Booij, Linda and Baker, Glen B. and Young, Simon N. and Benkelfat, Chawki",
volume="32",
number="2",
pages="129-136",
abstract="OBJECTIVE: Midbrain dopamine transmission is thought to regulate responses to rewarding drugs and drug-paired stimuli; however, the exact contribution, particularly in humans, remains unclear. In the present study, we tested whether decreasing dopamine synthesis, as produced by acute phenylalanine/tyrosine depletion (APTD), would alter responses to the stimulant drug, d-amphetamine. <br><br>METHODS: On 3 separate days, 14 healthy men received d-amphetamine (0.3 mg/kg, given orally) plus a nutritionally balanced amino acid mixture, the phenylalanine/tyrosine-deficient mixture or the phenylalanine/tyrosine-deficient mixture followed by the immediate dopamine precursor, L-DOPA (Sinemet, 2 x 100 mg/25 mg). Responses to these treatments were assessed with visual analog scales, the Profile of Mood States, and a computerized Go/No-Go task. <br><br>RESULTS: d-Amphetamine elicited its prototypical subjective effects, but these were not altered by APTD. In comparison, APTD significantly increased commission errors on the Go/No-Go task and did so uniquely in conditions where subjects were rewarded for making correct responses; this effect of APTD was prevented by L-DOPA. <br><br>CONCLUSIONS: Together these results support the hypothesis that, in healthy men, dopamine is not closely linked to euphorogenic effects of abused substances but does affect the salience of reward-related cues and the ability to respond to them preferentially.<p /><p>Language: en</p>",
language="en",
issn="1180-4882",
doi="",
url="http://dx.doi.org/"
}