@article{ref1,
title="Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial",
journal="American journal of emergency medicine",
year="2016",
author="Ocak, Tarik and Tekin, Erdal and Basturk, Mustafa and Duran, Arif and Serinken, Mustafa and Emet, Mucahit",
volume="34",
number="11",
pages="2140-2145",
abstract="BACKGROUND: There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. <br><br>OBJECTIVE: To compare effectiveness of &quot;oxygen alone&quot; vs &quot;metoclopramide plus oxygen&quot; vs &quot;metamizole plus oxygen&quot; therapy in treating carbon monoxide-induced headache. <br><br>DESIGN: A prospective, multicenter, double-blind, controlled trial. SETTING: Three emergency departments in Turkey. POPULATION: Adult carbon monoxide poisoning patients with headache. <br><br>METHODS: A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. MAIN OUTCOME MEASURE: The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. <br><br>RESULTS: During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. <br><br>CONCLUSION: The use of &quot;oxygen alone&quot; is as efficacious as &quot;oxygen plus metoclopramide&quot; or &quot;oxygen plus metamizole sodium&quot; in the treatment of carbon monoxide-induced headache.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0735-6757",
doi="10.1016/j.ajem.2016.08.002",
url="http://dx.doi.org/10.1016/j.ajem.2016.08.002"
}