@article{ref1,
title="Effects of social isolation, re-socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice",
journal="Animal science journal",
year="2016",
author="An, Dong and Chen, Wenxue and Yu, De-Qin and Wang, Shi-Wei and Yu, Wei-Zhi and Xu, Hong and Wang, Dong-Mei and Zhao, Dan and Sun, Yi-Ping and Wu, Jun-Cheng and Tang, Yi-Yuan and Yin, Sheng-Ming",
volume="88",
number="5",
pages="798-806",
abstract="Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress-associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age-matched controls were evaluated using object recognition, object location and resident-intruder tests. The recovery of behavioral deficits by re-socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re-socialization could completely recover spatial/non-spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non-spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.<br><br>© 2016 Japanese Society of Animal Science.<p /> <p>Language: en</p>",
language="en",
issn="1344-3941",
doi="10.1111/asj.12688",
url="http://dx.doi.org/10.1111/asj.12688"
}