@article{ref1,
title="Gonadotropin-releasing hormone agonist against severe aggression in autism",
journal="BMJ case reports",
year="2016",
author="van der Weiden, Robin M. F. and Helmerhorst, Frans M. and Eriksson, Tomas",
volume="2016",
number="ePub",
pages="ePub-ePub",
abstract="Aggression in patients with autism spectrum disorder (ASD) presents an important therapeutic challenge. Conventional treatment appears to be inadequate in a number of cases. The occurrence of severe aggressive symptoms since the inception of adolescence in a male patient with ASD suggested a hormonal influence by androgens. Conventional treatment with antipsychotic and antiepileptic drugs and benzodiazepines was ineffective. A subcutaneous long-acting gonadotropin-releasing hormone agonist (GnRH agonist) injection was given on a monthly basis resulting in a substantial improvement in his aggressive behaviour and renewed socialisation.<br><br>2016 BMJ Publishing Group Ltd.<p /> <p>Language: en</p>",
language="en",
issn="1757-790X",
doi="10.1136/bcr-2016-216378",
url="http://dx.doi.org/10.1136/bcr-2016-216378"
}