@article{ref1,
title="Networks underlying trait impulsivity: evidence from voxel-based lesion-symptom mapping",
journal="Human brain mapping",
year="2016",
author="McDonald, Valerie and Hauner, Katherina K. and Chau, Aileen and Krueger, Frank and Grafman, Jordan",
volume="38",
number="2",
pages="656-665",
abstract="Impulsivity is considered a multidimensional construct that encompasses a range of behaviors, including poor impulse control, premature decision-making, and the inability to delay gratification. In order to determine the extent to which impulsivity and its components share a common network, a voxel-based lesion-symptom mapping (VLSM) analysis was performed in a large sample of patients (N = 131) with focal, penetrating traumatic brain injuries (pTBI). Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11), a standard self-report measure that allows for unique estimates of global impulsivity and its factor analysis-derived components (e.g., &quot;motor impulsivity&quot;). Heightened global impulsivity was associated with damage to multiple areas in bilateral prefrontal cortex (PFC), left superior, middle and inferior temporal gyrus, and left hippocampus. Moreover, a cluster was identified within the left PFC associated specifically with motor impulsivity (defined as &quot;acting without thinking&quot;). The results were consistent with the existing literature on bilateral prefrontal cortical involvement in behavioral impulsivity, but also provided new evidence for a more complex neuroanatomical representation of this construct, characterized by left-lateralized temporal and hippocampal involvement, as well as a left-lateralized prefrontal network specifically associated with motor impulsivity. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.<br><br>© 2016 Wiley Periodicals, Inc.<p /> <p>Language: en</p>",
language="en",
issn="1065-9471",
doi="10.1002/hbm.23406",
url="http://dx.doi.org/10.1002/hbm.23406"
}