@article{ref1,
title="Modeling neurocognitive decline and recovery during repeated cycles of extended sleep and chronic sleep deficiency",
journal="Sleep",
year="2018",
author="St Hilaire, Melissa A. and Rüger, Melanie and Fratelli, Federico and Hull, Joseph T. and Phillips, Andrew J. K. and Lockley, Steven W.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="STUDY OBJECTIVES: Intra-individual night-to-night sleep duration is often insufficient and variable. Here we report the effects of such chronic variable sleep deficiency on neurobehavioral performance and the ability of state-of the-art models to predict these changes. <br><br>METHODS: Eight healthy males (mean age ± SD: 23.9 ± 2.4 years) studied on our inpatient intensive physiologic monitoring unit completed an 11-day protocol with a baseline 10-hour sleep opportunity and three cycles of two 3-hour time-in-bed and one 10-hour time-in-bed sleep opportunities. Participants received one of three polychromatic white light interventions (200 lux 4100K, 200 or 400 lux 17000K) for 3.5 hours on the morning following the second 3-hour time-in-bed opportunity each cycle. Neurocognitive performance was assessed using the psychomotor vigilance test (PVT) administered every 1-2 hours. PVT data were compared to predictions of five group-average mathematical models that incorporate chronic sleep loss functions. <br><br>RESULTS: While PVT performance deteriorated cumulatively following each cycle of two 3-hour sleep opportunities, and improved following each 10-hour sleep opportunity, performance declined cumulatively throughout the protocol at a more accelerated rate than predicted by state-of-the-art group-average mathematical models. Subjective sleepiness did not reflect performance. The light interventions had minimal effect. <br><br>CONCLUSIONS: Despite apparent recovery following each extended sleep opportunity, residual performance impairment remained and deteriorated rapidly when re-challenged with subsequent sleep loss. None of the group-average models were capable of predicting both the build-up in impairment and recovery profile of performance observed at the group or individual level, raising concerns regarding their use in real-world settings to predict performance and improve safety.<p /> <p>Language: en</p>",
language="en",
issn="0161-8105",
doi="",
url="http://dx.doi.org/"
}