@article{ref1,
title="Persistence of impulsivity in pediatric and adolescent patients with obsessive-compulsive disorder",
journal="Psychiatry and the Clinical Neurosciences",
year="2016",
author="Yamamuro, Kazuhiko and Ota, Toyosaku and Iida, Junzo and Kishimoto, Naoko and Nakanishi, Yoko and Kishimoto, Toshifumi",
volume="71",
number="1",
pages="36-43",
abstract="AIMS: Increasing clinical evidence points to impulsivity as a symptom of obsessive-compulsive disorder (OCD). However, little is known about its persistence over time. <br><br>METHODS: In this study, we evaluated the performance of 12 pediatric patients with OCD on the Stroop color-word task, which assesses impulsivity and compared this with age- and sex-matched controls. In parallel, we measured changes in hemodynamic responses during the task, using near-infrared spectroscopy. As patients in the OCD group were naïve to treatment, we compared results before and after three year medication with serotonin reuptake inhibitors (SSRI). <br><br>RESULTS: We report that, compared with controls, the OCD group had significantly poorer performance and less activation in the prefrontal cortex during the Stroop color-word task. Surprisingly, while SSRI treatment reduced OCD symptomology, it did not rescue the diminished hemodynamic responses or task performance of these patients. <br><br>CONCLUSIONS: Our findings suggest a persistent deficit exists in the inhibitory control of pediatric patients with OCD, and provide insight into the pathophysiology of OCD.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1323-1316",
doi="10.1111/pcn.12465",
url="http://dx.doi.org/10.1111/pcn.12465"
}