@article{ref1,
title="The neurobiology of self-processing in abused depressed adolescents",
journal="Development and psychopathology",
year="2016",
author="Quevedo, Karina and Ng, Rowena and Scott, Hannah and Smyda, Garry and Pfeifer, Jennifer H. and Malone, Sandra",
volume="29",
number="3",
pages="1057-1073",
abstract="Maltreatment is associated with chronic depression, high negative self-attributions, and lifetime psychopathology. Adolescence is a sensitive period for the formation of self-concept. Identifying neurobiomarkers of self-processing in depressed adolescents with and without maltreatment may parse the effects of trauma and depression on self-development and chronic psychopathology. Depressed adolescents (n = 86) maltreated due to omission (DO, n = 13) or commission (DCM, n = 28) or without maltreatment (DC, n = 45), and HCs (HC, n = 37) appraised positive and negative self-descriptors in the scanner. DCM and DO showed hypoactivity in the dorsal anterior cingulate cortex (dACC) while processing positive versus negative self-descriptors compared to DC youth, who in turn showed reduced dACC recruitment versus HC. HC youth showed the highest activation in the dACC and striatum during positive self-descriptors; these regions showed a linear decline in activity across DC, DO, and DCM. Low dACC activity to positive versus negative self-descriptors was linked to inadequate coregulation of children's emotions by parents. Negative self-cognitions prevalent in DCM and DO adolescents may be perpetuated by activity in the dACC and striatum. Reduced activation of the dACC and striatum for positive self-descriptors, coupled with enhanced activity for negative self-descriptors, may heighten the risk for persistent depression.<p /> <p>Language: en</p>",
language="en",
issn="0954-5794",
doi="10.1017/S0954579416001024",
url="http://dx.doi.org/10.1017/S0954579416001024"
}