@article{ref1,
title="Opioids and chronic pain: where is the balance?",
journal="Current oncology reports",
year="2016",
author="Davis, Mellar P. and Mehta, Zankhana",
volume="18",
number="12",
pages="71-71",
abstract="Chronic opioid therapy (defined as greater than 3 months on opioids) is a common practice for those with non-cancer pain, cancer survivors with treatment-related pain, and individuals with cancer undergoing disease-modifying therapy with a survival that can be for a year or more. Recent studies have found unique long-term toxicities with opioids which reduce the utility of opioid therapy in chronic pain. The risk of addiction, depression, central hypogonadism, sleep-disordered breathing, impaired wound healing, infections, cognitive impairment, falls, non-vertebral fractures, and mortality are increased in populations on long-term opioids. Factors associated with these risks are related to dose, duration of opioid therapy, type of opioid, and formula (long-acting, short-acting). This state-of-the-art review discusses the risks and benefits of chronic opioid therapy and strategies to increase utility and diminish risks to opioid therapy.<p /> <p>Language: en</p>",
language="en",
issn="1523-3790",
doi="10.1007/s11912-016-0558-1",
url="http://dx.doi.org/10.1007/s11912-016-0558-1"
}