@article{ref1,
title="Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support",
journal="Epigenomics",
year="2016",
author="Shields, Alexandra E. and Wise, Lauren A. and Ruiz-Narvaez, Edward A. and Seddighzadeh, Bobak and Byun, Hyang-Min and Cozier, Yvette C. and Rosenberg, Lynn and Palmer, Julie R. and Baccarelli, Andrea A.",
volume="8",
number="11",
pages="1507-1517",
abstract="AIM: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. MATERIALS & METHODS: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. <br><br>RESULTS: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. <br><br>CONCLUSION: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.<p /> <p>Language: en</p>",
language="en",
issn="1750-1911",
doi="10.2217/epi-2016-0074",
url="http://dx.doi.org/10.2217/epi-2016-0074"
}