@article{ref1,
title="Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40",
journal="Brain injury",
year="2016",
author="Lejbman, Natasha and Olivera, Anlys and Heinzelmann, Morgan and Feng, Rebekah and Yun, Sijung and Kim, Hyung-Suk and Gill, Jessica",
volume="30",
number="12",
pages="1436-1441",
abstract="PRIMARY OBJECTIVE: Excessive accumulation of amyloid beta (Aβ) and tau have been observed in older individuals with chronic neurological symptoms related to a traumatic brain injury (TBI), yet little is known about the possible role of Aβ in younger active duty service members following a TBI. The purpose of the study was to determine if Aβ 40 or 42 related to sustaining a TBI or to chronic neurological symptoms in a young cohort of military personnel. RESEARCH DESIGN: This was a cross-sectional study of active duty service members who reported sustaining a TBI and provided self-report of neurological and psychological symptoms and provided blood. <br><br>METHODS AND PROCEDURES: An ultrasensitive single-molecule enzyme-linked immunosorbent assay was used to compare concentrations of Aβ in active duty service members with (TBI+; n = 53) and without (TBI-; n = 18) a history of TBI. Self-report and medical history were used to measure TBI occurrence and approximate the number of total TBIs and the severity of TBIs sustained during deployment. MAIN OUTCOMES AND RESULTS: This study reports that TBI is associated with higher concentrations of Aβ40 (F1,68 = 6.948, p = 0.009) and a lower ratio of Aβ42/Aβ40 (F1,62 = 5.671, p = 0.020). These differences remained significant after controlling for co-morbid symptoms of post-traumatic stress disorder and depression. <br><br>CONCLUSIONS: These findings suggest that alterations in Aβ relate to TBIs and may contribute to chronic neurological symptoms.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2016.1219054",
url="http://dx.doi.org/10.1080/02699052.2016.1219054"
}