@article{ref1,
title="Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor",
journal="Journal of the neurological sciences",
year="2016",
author="Rohl, Brittany and Collins, Kathleen and Morgan, Sarah and Cosentino, Stephanie and Huey, Edward D. and Louis, Elan D.",
volume="371",
number="",
pages="24-31",
abstract="There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study. Cases underwent a comprehensive neuropsychological assessment, and were classified as ET with normal cognition (ET-NC), ET with mild cognitive impairment (ET-MCI), and ET with dementia (ET-D). PSQI scores did not significantly differ across the three ET cognitive groups (p=0.22). ESS scores were highest (more daytime sleepiness) in the ET-MCI group, followed by the ET-D and ET-NC groups, respectively (p=0.016). We examined sleep dysfunction across the cognitive spectrum in ET. We demonstrate for the first time that excessive daytime sleepiness is greater in ET-MCI than ET-NC. Unpredicted low ESS scores in the dementia group raises two possibilities: a self-report bias related to cognitive impairment and/or the possibility that currently undefined pathological heterogeneity in ET may map onto multiple presentations of non-motor deficits.<br><br>Copyright © 2016. Published by Elsevier B.V.<p /> <p>Language: en</p>",
language="en",
issn="0022-510X",
doi="10.1016/j.jns.2016.10.006",
url="http://dx.doi.org/10.1016/j.jns.2016.10.006"
}