@article{ref1,
title="Interaction of obstructive sleep apnoea and cognitive impairment with slow gait speed in middle-aged and older adults",
journal="Age and ageing",
year="2017",
author="Lee, Sunghee and Shin, Chol",
volume="46",
number="4",
pages="653-659",
abstract="OBJECTIVE: to investigate whether slow gait speed is associated with cognitive impairment and further whether the association is modified by obstructive sleep apnoea (OSA). <br><br>METHODS: in total, 2,222 adults aged 49-80 years, free from dementia, stroke and head injury were asked to walk a 4-m course at fast and usual gait speeds. The time taken to walk was measured. All participants completed the Korean Mini-Mental State Examination, which was validated in the Korean language, to assess cognitive function. Additionally, the participants completed a polysomnography test to ascertain OSA (defined as an apnoea-hypopnoea index ≥15). Multivariable linear regression models were utilised to test the associations. <br><br>RESULTS: time taken to walk 4 m showed significant inverse associations with cognitive scores (P value = 0.001 at fast gait speed and P = 0.002 at usual gait speed). Furthermore, a significant interaction according to OSA on the association between time to walk and cognitive impairment was found (P value for interaction = 0.003 at fast gait speed and P value for interaction = 0.007 at usual gait speed). <br><br>CONCLUSION: we found that the inverse association between the time taken to walk 4 m and a cognitive score became significantly stronger, if an individual had OSA.<br><br>© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.<p /> <p>Language: en</p>",
language="en",
issn="0002-0729",
doi="10.1093/ageing/afw228",
url="http://dx.doi.org/10.1093/ageing/afw228"
}