@article{ref1,
title="False negative on a proven involuntary intoxication in two children with lorazepam",
journal="Annales de Biologie Clinique",
year="2017",
author="Feliu, Catherine and Guillemin, Hélène and Gozalo, Claire and Fouley, Aurélie and Marty, Hélène and Millart, Hervé and Djerada, Zoubir",
volume="75",
number="1",
pages="83-86",
abstract="Children aged between 1 to 4 years are the most at risk of unintentional poisonings. Benzodiazepines are the most medicine often cause of the poisoning. Among the twenty-two most prescribed benzodiazepines in France, lorazepam ranks fifth behind zolpidem, alprazolam, bromazepam and zopiclone. However the automated assay currently available does not allow to detect and/or to quantify lorazepam. The alternative to the immunoassay is the liquid chromatography coupled with mass spectrometry (HPLC/MS). This technique, highly sensitive and specific, requires a pre-treatment phase and a good technical proficiency, justifying specialized staff. The clinical cases presented here illustrate the major interest of availability to this type of technology in routine and 24h/24h.<p /> <p>Language: en</p>",
language="en",
issn="0003-3898",
doi="10.1684/abc.2016.1209",
url="http://dx.doi.org/10.1684/abc.2016.1209"
}