@article{ref1,
title="Injury severity, sex, and transfusion volume, but not transfusion ratio, predict inflammatory complications after traumatic injury",
journal="Heart and lung",
year="2017",
author="Jones, Allison R. and Bush, Heather M. and Frazier, Susan K.",
volume="46",
number="2",
pages="114-119",
abstract="BACKGROUND: Blood component (packed red blood cells [PRBC], fresh frozen plasma [FFP], platelets [PLT]) ratios transfused in a 1:1:1 fashion are associated with survival after trauma; the relationship among blood component ratios and inflammatory complications after trauma is not fully understood. <br><br>OBJECTIVES: To evaluate the relationship among blood component ratios (1:1 vs other for PRBC:FFP and PRBC:PLT) and inflammatory complications (primary outcome) in patients with major trauma. <br><br>METHODS: Secondary analysis of a multi-institution database (N = 1538). Survival methods were used to determine the relationship among blood component ratios and inflammatory complications. <br><br>RESULTS: Patients were primarily male (68%), Caucasians (89%), aged 39 ± 14 years, involved in a motor vehicle collision (53%). Eighty-six percent of patients developed an inflammatory complication; 76% developed organ failure, 27% ventilator-associated pneumonia, and 24% acute respiratory distress syndrome. Injury severity, sex, and total PRBC transfusion volume, not blood component ratio, predicted inflammatory complications. <br><br>CONCLUSIONS: Increased understanding of factors associated with inflammation after trauma and PRBC transfusion is needed.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0147-9563",
doi="10.1016/j.hrtlng.2016.12.002",
url="http://dx.doi.org/10.1016/j.hrtlng.2016.12.002"
}