@article{ref1,
title="Use of selective serotonin reuptake inhibitors and risk of hip fracture in the elderly: a case-control study in Taiwan",
journal="Journal of the American Medical Directors Association",
year="2017",
author="Hung, Shih-Chang and Lin, Chih-Hsueh and Hung, Hung-Chang and Lin, Cheng-Li and Lai, Shih-Wei",
volume="18",
number="4",
pages="350-354",
abstract="BACKGROUND: This population based study investigated the relationship between use of selective serotonin reuptake inhibitors (SSRIs) and hip fractures in the elderly in Taiwan. <br><br>METHODS: Analysis of a random sample of 1 million insurance enrollees' data identified 4,891 patients with newly diagnosed hip fractures and 4,891 controls without hip fracture between 2000 and 2011. Both cases and controls were ≥65 years of age and were matched by sex, age, comorbidities, and index year of hip fracture diagnosis. Patients were considered current SSRI users if their last SSRI tablet was taken ≤7 days before the hip fracture diagnosis. Late use of SSRIs was defined as taking the last SSRI tablet ≥8 days before the hip fracture diagnosis. Non-SSRI users comprised individuals who never had an SSRI prescription. Odds ratios (ORs) and 95% confidence intervals (CIs) for hip fracture associated with SSRI use was estimated by multivariate unconditional logistic regression. <br><br>RESULTS: After adjustment for covariants, multivariate regression analysis showed that the adjusted OR of hip fracture was 2.17 for current SSRI users (95% CI: 1.60-2.93) compared with those who never used SSRIs. The adjusted OR was 1.11 for individuals with late use of SSRIs (95% CI: 0.96-1.28) and was not significant. <br><br>CONCLUSIONS: Current use of SSRIs was associated with a 2.17-fold increase in the odds of hip fracture in the elderly in Taiwan. Clinicians should consider the possibility of SSRI-associated hip fracture among old people currently taking SSRIs.<br><br>Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1525-8610",
doi="10.1016/j.jamda.2016.12.003",
url="http://dx.doi.org/10.1016/j.jamda.2016.12.003"
}