@article{ref1,
title="Gene-gene-environment interactions of serotonin transporter, monoamine oxidase A and childhood maltreatment predict aggressive behavior in Chinese adolescents",
journal="Frontiers in behavioral neuroscience",
year="2017",
author="Zhang, Yun and Ming, Qing-Sen and Yi, Jin-Yao and Wang, Xiang and Chai, Qiao-Lian and Yao, Shu-Qiao",
volume="11",
number="",
pages="e17-e17",
abstract="Gene-environment interactions that moderate aggressive behavior have been identified independently in the serotonin transporter (5-HTT) gene and monoamine oxidase A gene (MAOA). The aim of the present study was to investigate epistasis interactions between MAOA-variable number tandem repeat (VNTR), 5-HTTlinked polymorphism (LPR) and child abuse and the effects of these on aggressive tendencies in a group of otherwise healthy adolescents. A group of 546 Chinese male adolescents completed the Child Trauma Questionnaire and Youth self-report of the Child Behavior Checklist. Buccal cells were collected for DNA analysis. The effects of childhood abuse, MAOA-VNTR, 5-HTTLPR genotypes and their interactive gene-gene-environmental effects on aggressive behavior were analyzed using a linear regression model. The effect of child maltreatment was significant, and a three-way interaction among MAOA-VNTR, 5-HTTLPR and sexual abuse (SA) relating to aggressive behaviors was identified. Chinese male adolescents with high expression of the MAOA-VNTR allele and 5-HTTLPR &quot;SS&quot; genotype exhibited the highest aggression tendencies with an increase in SA during childhood. The findings reported support aggression being a complex behavior involving the synergistic effects of gene-gene-environment interactions.<p /> <p>Language: en</p>",
language="en",
issn="1662-5153",
doi="10.3389/fnbeh.2017.00017",
url="http://dx.doi.org/10.3389/fnbeh.2017.00017"
}