@article{ref1,
title="Sex-specific impact of early-life adversity on chronic pain: a large population-based study in Japan",
journal="Journal of pain research",
year="2017",
author="Yamada, Keiko and Matsudaira, Ko and Tanaka, Eizaburo and Oka, Hiroyuki and Katsuhira, Junji and Iso, Hiroyasu",
volume="10",
number="",
pages="427-433",
abstract="BACKGROUND: Responses to early-life adversity may differ by sex. We investigated the sex-specific impact of early-life adversity on chronic pain, chronic multisite pain, and somatizing tendency with chronic pain. <br><br>METHODS: We examined 4229 respondents aged 20-79 years who participated in the Pain Associated Cross-Sectional Epidemiological Survey in Japan. Outcomes were: 1) chronic pain prevalence, 2) multisite pain (≥3 sites) prevalence, and 3) multiple somatic symptoms (≥3 symptoms) among respondents with chronic pain related to the presence or absence of early-life adversity. Multivariable-adjusted odds ratios (ORs) were calculated with 95% confidence intervals using a logistic regression model including age, smoking status, exercise routine, sleep time, body mass index, household expenditure, and the full distribution of scores on the Mental Health Inventory-5. We further adjusted for pain intensity when we analyzed the data for respondents with chronic pain. <br><br>RESULTS: The prevalence of chronic pain was higher among respondents reporting the presence of early-life adversity compared with those reporting its absence, with multivariable ORs of 1.62 (1.22-2.15, p<0.01) in men and 1.47 (1.13-1.90, p<0.01) in women. Among women with chronic pain, early-life adversity was associated with multisite pain and multiple somatic symptoms; multivariable ORs were 1.78 (1.22-2.60, p<0.01) for multisite pain and 1.89 (1.27-2.83, p<0.01) for ≥3 somatic symptoms. No associations were observed between early-life adversity and chronic multisite pain or multiple somatic symptoms among men with chronic pain. <br><br>CONCLUSION: Early-life adversity may be linked to a higher prevalence of chronic pain among both sexes and to multisite pain and somatizing tendency among women with chronic pain.<p /> <p>Language: en</p>",
language="en",
issn="1178-7090",
doi="10.2147/JPR.S125556",
url="http://dx.doi.org/10.2147/JPR.S125556"
}