@article{ref1,
title="Trends in antipsychotic prescriptions for Japanese outpatients during 2006-2012: a descriptive epidemiological study",
journal="Pharmacoepidemiology and drug safety",
year="2017",
author="Kochi, Kenji and Sato, Izumi and Nishiyama, Chika and Tanaka-Mizuno, Sachiko and Doi, Yuko and Arai, Masaru and Fujii, Yosuke and Matsunaga, Toshiyuki and Ogawa, Yusuke and Furukawa, Toshi A. and Kawakami, Koji",
volume="26",
number="6",
pages="642-656",
abstract="PURPOSE: This study aimed to assess the trends in antipsychotic prescriptions for outpatients in Japan, where a community-based approach to mental healthcare is emphasized. <br><br>METHODS: This descriptive epidemiological study used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and receiving their initial antipsychotic prescription during 2006-2012 were evaluated. The annual trends were reported for monotherapies, polypharmacy, antipsychotic doses, and the concurrent prescription of psychotropic medications. <br><br>RESULTS: The 152 592 outpatients included 101 133 (66%) adults (18-64 years old) and 51 459 (34%) older adults (≥65 years old). Among the adults, second-generation antipsychotic monotherapy prescriptions increased from 49% in 2006 to 71% in 2012, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 14%, and antipsychotic polypharmacy decreased from 23 to 15%, respectively. Among the older adults, second-generation antipsychotic monotherapy prescriptions increased from 64 to 82%, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 12%, and antipsychotic polypharmacy decreased from 7 to 6%, respectively. During the study period, >80% of the adults and >90% of the older adults received antipsychotics at risperidone-equivalent doses of <6 mg/day. Anxiolytics/hypnotics, antidepressants, antiparkinson agents, mood stabilizers, and anti-dementia agents were concurrently prescribed with antipsychotics for 70, 33, 20, 20, and 0.3% of the adults and for 43, 16, 19, 8, and 16% of the older adults, respectively. <br><br>CONCLUSIONS: The present study evaluated large-scale claims-based datasets and found that high-dose prescriptions and antipsychotic polypharmacy among Japanese outpatients were not as prevalent as has been previously thought. Copyright © 2017 John Wiley & Sons, Ltd. StartCopTextCopyright © 2017 John Wiley & Sons, Ltd.<br><br>Copyright © 2017 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>",
language="en",
issn="1053-8569",
doi="10.1002/pds.4187",
url="http://dx.doi.org/10.1002/pds.4187"
}