@article{ref1,
title="Baclofen and alcohol-dependent patients: a real risk of severe self-poisoning",
journal="Basic and Clinical Pharmacology and Toxicology",
year="2017",
author="Boels, David and Victorri-Vigneau, Caroline and Grall-Bronnec, Marie and Touré, Ali and Garnier, Anais and Turcant, Alain and Le Roux, Gaël",
volume="121",
number="4",
pages="353-359",
abstract="Baclofen is often prescribed in high doses to fight cravings experienced by alcohol-dependent patients. Such an increase in the availability of baclofen is concerning. This study aimed to determine the change in number and profile of self-poisoning with baclofen over time, since baclofen has become increasingly popular, in order to describe the severity of self-poisoning with baclofen and to focus on co-existing alcohol use disorders and psychiatric illnesses determine predictors of severity. This was a retrospective study of self-poisoning with baclofen as reported by the western France Poison Control Center (PCC), which represents a population of more than 12 million people from January 2008 to March 2014. 111 cases of self-poisoning with baclofen were reported to the western France PCC (62 males and 49 females; average age 39±12). Poisoning severities were: &quot;null&quot; (9 cases), &quot;minor&quot; (37 cases), &quot;moderate&quot; (19 cases) and &quot;high&quot; (46 cases, including 4 deaths). The most frequently reported symptoms were neurological (45%) and cardiovascular (27%). The severity was significantly associated with psychiatric disorders (OR=2.9; p=0.03). Baclofen, prescribed in high doses, may lead to severe poisoning, particularly in patients with psychiatric illnesses. Authorities should put forward a new policy for prescribing the drug as a treatment for alcohol dependence. This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1742-7835",
doi="10.1111/bcpt.12779",
url="http://dx.doi.org/10.1111/bcpt.12779"
}