@article{ref1,
title="Socio-demographic and clinical characterization of patients with Bipolar Disorder I vs II: a nationwide Italian study",
journal="European archives of psychiatry and clinical neuroscience",
year="2018",
author="Altamura, A. Carlo and Buoli, Massimiliano and Cesana, Bruno and Dell'osso, Bernardo and Tacchini, Gianluigi and Albert, Umberto and Fagiolini, Andrea and de Bartolomeis, Andrea and Maina, Giuseppe and Sacchetti, Emilio",
volume="268",
number="2",
pages="169-177",
abstract="Bipolar disorders (BDs) are prevalent, comorbid and disabling conditions, associated with the highest suicide risk among psychiatric illnesses. In the last few years, new efforts to better characterize the socio-demographic and clinical profiles of BD type I vs II have been documented by several reports, with novel and insightful findings in the field. The present multicenter study aimed to provide a comprehensive and reliable representation of the Italian reality, through the analysis of the largest national sample of bipolar patients collected so far. A total of 1500 patients (BD I n = 963 and BD II n = 537) from different psychiatric departments, participating in the Italian Chapter of the &quot;International Society of Bipolar Disorders&quot; (ISBD), were assessed and divided into two groups on the basis of their diagnostic subtype, and different socio-demographic and clinical variables were compared between the two subgroups. Chi-squared tests for categorical variables and t tests for continuous variables were performed for group comparison. Furthermore, a multivariable logistic regression was performed, considering diagnostic bipolar subtype (type I or II) as dependent variable, and socio-demographic/clinical characteristics as independent variables. BD I vs II patients showed an overall less favorable socio-demographic and clinical profile. In addition, the multivariable logistic regression showed that BD II vs BD I was predicted by the absence of lifetime suicide attempts (OR = 1.58, p = 0.01), a later age of diagnosis (OR = 1.03, p < 0.01), less hypomanic episodes in the last year (OR = 2.29, p < 0.0001) and absence of psycho-educational interventions in the last year (OR = 0.51, p < 0.01). BD I and II patients were found to significantly differ in relation to specific clinical variables, which should be considered within updated diagnostic-therapeutic algorithms.<p /> <p>Language: en</p>",
language="en",
issn="0940-1334",
doi="10.1007/s00406-017-0791-0",
url="http://dx.doi.org/10.1007/s00406-017-0791-0"
}