@article{ref1,
title="Neural reactivity to reward and internalizing symptom dimensions",
journal="Journal of affective disorders",
year="2017",
author="Burkhouse, Katie L. and Gorka, Stephanie M. and Afshar, Kaveh and Phan, K. Luan",
volume="217",
number="",
pages="73-79",
abstract="BACKGROUND: Reduced reward responsiveness, measured via the event-related potential (ERP) component the reward positivity (RewP), has been linked to several internalizing psychopathologies (IPs). Specifically, prior studies suggest that a reduced RewP is robustly related to depression and to a lesser extent anxiety. No studies to date, however, have examined the relation between the RewP and IP symptom dimensions in a heterogeneous, clinically representative patient population that includes both depressed and/or anxious subjects. The primary aim of the current study was to examine the relation between the RewP and specific internalizing symptom dimensions among patients with a variety of IP diagnoses and symptoms. <br><br>METHODS: A total of 80 treatment seeking adults from the community completed a battery of questionnaires assessing a range of IP symptoms and a well-validated reward processing task known to robustly elicit the RewP. <br><br>RESULTS: A principal components analysis (PCA) on clinical assessments revealed two distinct factors that characterized the patient sample: affective distress/misery and fear-based anxiety. <br><br>RESULTS showed that within this sample, an attenuated RewP was associated with greater affective distress/misery based symptoms; however, the RewP was unrelated to fear-based anxiety symptoms. <br><br>CONCLUSIONS: The current findings suggest that patients with higher distress/misery symptoms are characterized by decreased responsivity to rewards at the physiological level, and that this response tendency distinguishes distress/misery symptoms from fear-based symptoms. The RewP may be one promising transdiagnostic biological target for intervention efforts for individuals with distress-based symptoms of psychopathology.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2017.03.061",
url="http://dx.doi.org/10.1016/j.jad.2017.03.061"
}