@article{ref1,
title="Chronic traumatic encephalopathy: known causes, unknown effects",
journal="Physical medicine and rehabilitation clinics of North America",
year="2017",
author="Iacono, Diego and Shively, Sharon B. and Edlow, Brian L. and Perl, Daniel P.",
volume="28",
number="2",
pages="301-321",
abstract="Chronic traumatic encephalopathy (CTE) is a neuropathologic diagnosis typically made in human brains with a history of repetitive traumatic brain injury (rTBI). It remains unknown whether CTE occurs exclusively after rTBI, or whether a single TBI (sTBI) can cause CTE. Similarly, it is unclear whether impact (eg, motor vehicle accidents) and non-impact (eg, blasts) types of energy transfer trigger divergent or common pathologies. While it is established that a history of rTBI increases the risk of multiple neurodegenerative diseases (eg, dementia, parkinsonism, and CTE), the possible pathophysiologic and molecular mechanisms underlying these risks have yet to be elucidated.<br><br>Published by Elsevier Inc.<p /> <p>Language: en</p>",
language="en",
issn="1047-9651",
doi="10.1016/j.pmr.2016.12.007",
url="http://dx.doi.org/10.1016/j.pmr.2016.12.007"
}