@article{ref1,
title="Pathophysiology, diagnostic work-up and management of balance impairments and falls in patients with hereditary spastic paraplegia",
journal="Journal of rehabilitation medicine",
year="2017",
author="Nonnekes, Jorik and van Lith, Bas and van de Warrenburg, Bart P. and Weerdesteyn, Vivian and Geurts, Alexander C. H.",
volume="49",
number="5",
pages="369-377",
abstract="INTRODUCTION: Balance impairments are common in patients with hereditary spastic paraplegia and are among the most debilitating symptoms, as they frequently result in falls and fall-related injuries. Several features of hereditary spastic paraplegia contribute to balance impairments and multiple treatment options exist. However, an overview of these underlying mechanisms and their treatment is currently lacking. <br><br>METHODS: This paper reviews the pathophysiology, diagnostic workup, and management of balance impairments in hereditary spastic paraplegia. Recommendations are based on scientific evidence, when available, and otherwise reflect practice-based evidence supported by clinical experience. <br><br>CONCLUSION: Through diligent history-taking and clinical examination, followed by multidisciplinary treatment tailored to the identified underlying mechanisms, balance capacities can be improved in patients with hereditary spastic paraplegia and at least a proportion of falls can be prevented.<p /> <p>Language: en</p>",
language="en",
issn="1650-1977",
doi="10.2340/16501977-2227",
url="http://dx.doi.org/10.2340/16501977-2227"
}