@article{ref1,
title="Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC-MS/MS in case of severe intoxications",
journal="Journal of chromatography B: analytical technologies in the biomedical and life sciences",
year="2017",
author="Wiergowski, Marek and Aszyk, Justyna and Kaliszan, Michał and Wilczewska, Kamila and Anand, Jacek Sein and Kot-Wasik, Agata and Jankowski, Zbigniew",
volume="1041-1042",
number="",
pages="1-10",
abstract="This paper describes cases of poisoning caused by new psychoactive substances such as: 25B-NBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4‐CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC-MS/MS technique. To the best of our knowledge, this is the first report, that involves a fully validated method for quantification of new-designer drug - 4-CMC in postmortem blood samples. The biological material was also analyzed with the use of routine analytical methods: immunochemical techniques, gas chromatography with flame ionization detection and gas chromatography with electron impact mass spectrometry. The results of real samples analyses correspond to possible toxicological effects: death resulting from 25B-NBOMe - mediated hallucinations (661 ng/mL of 25B‐NBOMe and 0.887 ng/mL of 4-CMC), fatal overdose of 25B-NBOMe and 4-CMC (66.5 ng/mL of 25B‐NBOMe and 2.14 ng/mL of 4-CMC) and non-fatal intoxication of these drugs (38.4 ng/mL of 25B NBOMe and 0.181 ng/mL of 4-CMC). Additionally, O-demethylathed O, O-bis-demethylathed and glucuronidated metabolites of 25B-NBOMe in biological specimens were detected.<p /> <p>Language: en</p>",
language="en",
issn="1570-0232",
doi="10.1016/j.jchromb.2016.12.018",
url="http://dx.doi.org/10.1016/j.jchromb.2016.12.018"
}