@article{ref1,
title="Evidence for ancestral programming of resilience in a two-hit stress model",
journal="Frontiers in behavioral neuroscience",
year="2017",
author="Faraji, Jamshid and Soltanpour, Nabiollah and Ambeskovic, Mirela and Zucchi, Fabiola C. R. and Beaumier, Pierre and Kovalchuk, Igor and Metz, Gerlinde A. S.",
volume="11",
number="",
pages="e89-e89",
abstract="In a continuously stressful environment, the effects of recurrent prenatal stress (PS) may accumulate across generations and alter stress vulnerability and resilience. Here, we report in female rats that a family history of recurrent ancestral PS facilitates certain aspects of movement performance, and that these benefits are abolished by the experience of a second hit, induced by a silent ischemia during adulthood. Female F4-generation rats with and without a family history of cumulative multigenerational PS (MPS) were tested for skilled motor function before and after the induction of a minor ischemic insult by endothelin-1 infusion into the primary motor cortex. MPS resulted in improved skilled motor abilities and blunted hypothalamic-pituitary-adrenal (HPA) axis function compared to non-stressed rats. Deep sequencing revealed downregulation of miR-708 in MPS rats along with upregulation of its predicted target genes Mapk10 and Rasd2. Through miR-708 stress may regulate mitogen-activated protein kinase (MAPK) pathway activity. Hair trace elemental analysis revealed an increased Na/K ratio, which suggests a chronic shift in adrenal gland function. The ischemic lesion activated the HPA axis in MPS rats only; the lesion, however, abolished the advantage of MPS in skilled reaching. The findings indicate that MPS generates adaptive flexibility in movement, which is challenged by a second stressor, such as a neuropathological condition. Thus, a second &quot;hit&quot; by a stressor may limit behavioral flexibility and neural plasticity associated with ancestral stress.<p /> <p>Language: en</p>",
language="en",
issn="1662-5153",
doi="10.3389/fnbeh.2017.00089",
url="http://dx.doi.org/10.3389/fnbeh.2017.00089"
}