@article{ref1,
title="Decrease in brain-derived neurotrophic factor at plasma level but not in serum concentrations in suicide behavior: a systematic review and meta-analysis",
journal="Brain and behavior",
year="2017",
author="Salas-Magaña, Marisol and Tovilla-Zárate, Carlos A. and González-Castro, Thelma B. and Juárez-Rojop, Isela E. and López-Narváez, María L. and Rodríguez-Pérez, José M. and Ramírez Bello, Julián",
volume="7",
number="6",
pages="e00706-e00706",
abstract="Introduction  Suicide is known as a major health concern worldwide. There is evidence for the role of brain-derived neurotrophic factor (BDNF) in suicide behavior. Therefore, this factor has been proposed as a biomarker for suicide behavior. Clinical studies have measured BDNF concentrations at central and peripheral levels. As a consequence, the aim of this study was to assess BDNF levels in blood plasma and serum to see whether there is a difference in concentrations in patients with suicide behavior when compared to those in controls, using a meta-analysis approach.    Methods  We conducted a systematic review and meta-analysis. The search strategy was performed using three databases: PubMed, EBSCO and ScienceDirect. The meta-analysis included a total of nine case-control studies, six measured the BDNF level in serum and three in plasma in suicide behavior.    Results  A decrease in BDNF levels in plasma was observed (d = −0.73, 95% CI −1.42 to −0.03 pg/ml). In the case of serum concentrations, no BDNF differences were encountered between cases and controls (d = 0.09, 95% CI −0.31 to 0.13 ng/ml, p(Q) = .92).    Conclusions  According to the results found in the present meta-analysis, the plasma BDNF level could be suggest as a potential biomarker in suicide behavior. However, since the number of studies included in the analysis is limited, a larger number is necessary to determine conclusively the role of BDNF as a biomarker in suicide behavior.<p /> <p>Language: en</p>",
language="en",
issn="2162-3279",
doi="10.1002/brb3.706",
url="http://dx.doi.org/10.1002/brb3.706"
}