@article{ref1,
title="The long-term effects of mandibular advancement splint on cardiovascular fitness and psychomotor performance in patients with mild to moderate obstructive sleep apnea: a prospective study",
journal="Sleep and Breathing",
year="2017",
author="Gupta, Ashutosh and Tripathi, Arvind and Sharma, Piyush",
volume="21",
number="3",
pages="781-789",
abstract="BACKGROUND: Obstructive sleep apnea (OSA) manifests as a reduction or complete cessation of airflow despite an ongoing inspiratory effort, leading to hypoxemia and hypercapnia. The inability to maintain normal breathing reduces the oxygen saturation in blood leading to a cycle of various systemic implications. Hence, a prospective single arm study was planned to evaluate the long-term (2 years) effect of oral appliance on cardiovascular fitness and psychomotor performance in patients with mild to moderate obstructive sleep apnea. <br><br>METHODS: Thirty dentulous OSA patients (25 males; 5 females; age 41 ± 4 years; BMI 22 ± 5; AHI 5-30) were included in the study. All the patients were assessed for systolic blood pressure (SBP), diastolic blood pressure (DBP), apnea/hypopnea index (AHI), lipid peroxidation, and psychomotor vigilance test at baseline, 6 months, 1 year, and 2 years after wearing mandibular advancement splint (MAS). <br><br>RESULTS: A significant reduction in AHI, blood pressure, and lipid peroxidation was observed following MAS use. Psychomotor vigilance test showed marked improvement in response time with almost 0 count of lapses after 2 years of MAS use. <br><br>CONCLUSIONS: The present study suggested that MAS can be helpful in improving cardiovascular fitness and cognitive response in patients with mild to moderate OSA.<p /> <p>Language: en</p>",
language="en",
issn="1520-9512",
doi="10.1007/s11325-017-1534-1",
url="http://dx.doi.org/10.1007/s11325-017-1534-1"
}