@article{ref1,
title="Performance evaluation of a pre-computed brain response atlas in dummy head impacts",
journal="Annals of biomedical engineering",
year="2017",
author="Zhao, Wei and Kuo, Calvin and Wu, Lyndia and Camarillo, David B. and Ji, Songbai",
volume="45",
number="10",
pages="2437-2450",
abstract="A pre-computed brain response atlas (pcBRA) may have the potential to accelerate the investigation of the biomechanical mechanisms of traumatic brain injury on a large-scale. In this study, we further enhance the technique and evaluate its performance using six degree-of-freedom angular velocity profiles from dummy head impacts. Using the pcBRA to simplify profiles into acceleration-only shapes, sufficiently accurate strain estimates were obtained for impacts with a major dominating velocity peak. However, they were largely under-estimated when substantial deceleration occurred that reversed the direction of the angular velocity. For these impacts, estimation accuracy was substantially improved with a biphasic profile simplification (average correlation coefficient and linear regression slope of 0.92 ± 0.03 and 0.95 ± 0.07 for biphasic shapes, respectively, vs. 0.80 ± 0.06 and 0.80 ± 0.08 for acceleration-only shapes). Peak maximum principal strain (ɛ p) and cumulative strain damage measure (CSDM) from the estimated strains consistently correlated stronger than kinematic metrics with respect to the baseline ɛ p and CSDM from the directly simulated responses, regardless of the brain region, and by a large margin (e.g., correlation of 0.93 vs. 0.75 compared to Brain Injury Criterion (BrIC) for ɛ p in the whole-brain, and 0.91 vs. 0.47 compared to BrIC for CSDM in the corpus callosum). These findings further support the pre-computation technique for accurate, real-time strain estimation, which could be important to accelerate model-based brain injury studies in the future.<p /> <p>Language: en</p>",
language="en",
issn="0090-6964",
doi="10.1007/s10439-017-1888-3",
url="http://dx.doi.org/10.1007/s10439-017-1888-3"
}