@article{ref1,
title="Lack of effects of a "sobering" product, "Eezup!", on the blood ethanol and congener alcohol concentration",
journal="Forensic science international",
year="2017",
author="Wunder, Cora and Hain, Sarah and Koelzer, Sarah C. and Paulke, Alexander and Verhoff, Marcel A. and Toennes, Stefan W.",
volume="278",
number="",
pages="101-105",
abstract="INTRODUCTION: The lifestyle product 'Eezup!' appeared on the German market and promised to normalize energy metabolism. Among vitamins (B1, B2, B6, C, E and zinc), rice protein and fructose the addition of alcohol dehydrogenase and catalase enzymes is a novel approach. The product was advertised as capable of boosting the rate of alcohol elimination. <br><br>METHODS: Seventeen subjects (11 men, 6 women, 19-58 years old), participated in a two-way crossover drinking study. Unfiltered wheat beer (4.4g% alcohol content) was drank within one hour to reach blood alcohol concentrations of 1‰ (1g/kg whole blood). On one day &quot;Eezup!&quot; was taken according to the manufacturer's instructions before and after drinking which was substituted for a placebo on the second test day. Blood samples were taken during 9h and ethanol and congener alcohols were determined. A comparison of Cmax, tmax, area under the curve (AUC) for ethanol and congener alcohols, and the hourly elimination rate of ethanol (β60) was performed to investigate an effect of Eezup!. <br><br>RESULTS: Ethanol concentrations (Cmax) were in the range of 0,63-1,00‰ (median 0,85‰) and 0.62-1.22‰ (median 0.84‰) in the placebo and &quot;Eezup!&quot; condition, respectively, and not statistically different. Also tmax (1-2.5h) and AUCs did not differ. The ethanol elimination rates were 0.16‰/h (0.14-0.19‰/h) and 0.17‰/h (0.14-0.22 ‰/h) in the placebo and &quot;Eezup!&quot; condition without significant difference. The pharmacokinetic parameters of the congener alcohols (1-propanol, isobutanol, 3-methyl-1-butanol, 2-methyl-1-butanol) as well as of methanol did also not differ. <br><br>CONCLUSIONS: The results of the present study failed to show any effect of the sobering product &quot;Eezup!&quot; on the amount of ethanol and congener alcohols absorbed (Cmax, tmax, AUC) and on the ethanol elimination rate (β60).<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0379-0738",
doi="10.1016/j.forsciint.2017.06.024",
url="http://dx.doi.org/10.1016/j.forsciint.2017.06.024"
}