@article{ref1,
title="Psychomotor vigilance test and its association with daytime sleepiness and inflammation in sleep apnea: clinical implications",
journal="Journal of clinical sleep medicine",
year="2017",
author="Li, Yun and Vgontzas, Alexandros and Kritikou, Ilia and Fernandez-Mendoza, Julio and Basta, Maria and Pejovic, Slobodanka and Gaines, Jordan and Bixler, Edward O.",
volume="13",
number="9",
pages="1049-1056",
abstract="STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA. <br><br>METHODS: We studied 58 untreated patients with OSA who underwent an 8-hour in-laboratory polysomnography for 4 consecutive nights. MSLT, PVT, and 24-hour serial profiles of IL-6 were assessed on the fourth day. PVT variables included number of lapses, mean reciprocal of the fastest 10% and slowest 10% reaction times, and median of 1/reaction time. ESS was assessed on day 1 of the study. <br><br>RESULTS: Higher ESS scores were significantly associated with greater number of lapses (β =.34, P =.02) and lower values of 1/RT (β = -.36, P =.01) and slowest 10% RTs (β = -.30, P =.04). No significant association was observed between PVT and MSLT, nor PVT and IL-6 levels. <br><br>CONCLUSIONS: Our findings suggest that PVT is associated with subjectively assessed daytime sleepiness, but not with physiological sleepiness nor IL-6 levels in patients with OSA. It appears that ESS and PVT may be useful in predicting risks associated with impaired performance, such as traffic accidents, in patients with OSA.<p /> <p>Language: en</p>",
language="en",
issn="1550-9389",
doi="",
url="http://dx.doi.org/"
}