@article{ref1,
title="Association of gait speed, psychomotor speed, and dementia",
journal="Journal of Alzheimer's disease",
year="2017",
author="Kuate-Tegueu, Callixte and Avila-Funes, José-Alberto and Simo, Nadine and Le Goff, Mélanie and Amieva, Hélène and Dartigues, Jean-François and Tabue-Teguo, Maturin",
volume="60",
number="2",
pages="585-592",
abstract="BACKGROUND: Gait speed (GS) and psychomotor speed (PS) could be considered as two different dimensions of age-related slowness and both measures are associated with higher risk of adverse health-related outcomes among elderly people. <br><br>OBJECTIVE: To determine the association between GS, PS, and incident dementia among community-dwelling older adults. <br><br>METHODS: Twelve-year longitudinal study of 1,265 participants in the Bordeaux Three-City Study, a French prospective to determine the risk of dementia and cognitive impairment attributable to cardiovascular risk factors. Participants completed a battery of cognitive tests, including time to complete the Trail Making Test A, and a walking speed test. The incidence of dementia was determined over the 12-year follow-up period. Cox proportional hazards models with delayed entry were used to estimate the cumulative risk of dementia and were adjusted for sex, education, and ApoE4 genotype. <br><br>RESULTS: Mean age of participants was 74.0 years (SD 4.8). Over the 12-year follow-up, 203 participants developed dementia. GS and PS were both independent predictors of incident all-cause dementia after 12 years of follow-up. For a one SD increase of either GS or PS, the hazard ratio (HR) for Alzheimer's disease was 1.2 (95% CI = 1.02-1.32) and 1.4 (95% CI = 1.2-1.61), respectively; whereas for incident vascular dementia, the HR was 1.3 (95% CI = 1.05-1.71) and 1.5 (95% CI = 1.16-2.08), respectively. No significant interaction between GS and PS was observed. <br><br>CONCLUSIONS: In older French people aged 65+, our findings showed that both low GS and PS were independently associated with risk of incident of Alzheimer's disease and vascular dementia.<p /> <p>Language: en</p>",
language="en",
issn="1387-2877",
doi="10.3233/JAD-170267",
url="http://dx.doi.org/10.3233/JAD-170267"
}