@article{ref1,
title="Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure",
journal="Neuropsychiatric disease and treatment",
year="2017",
author="Chen, Wei and Li, Ming-De and Wang, Gui-Fang and Yang, Xia-Feng and Liu, Lin and Meng, Fan-Gang",
volume="13",
number="",
pages="2301-2306",
abstract="BACKGROUND: To explore the incidence and risk factors, including type of seizures for post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI). <br><br>SUBJECTS AND METHODS: This was a retrospective follow-up study of patients discharged from Liaocheng People's Hospital between March 2011 and June 2015 with a diagnosis of post-traumatic seizures. Risk factors for PTE were evaluated in 68 inpatients by using Kaplan-Meier curves and the Cox model. <br><br>RESULTS: Complete clinical information was available for 68 patients. A total of 54 cases (79.4%) were diagnosed as presenting with PTE, occurring from 10 days to 179 months after severe TBI. Nineteen out of 54 cases (35.2%) had been defined as PTE within the first 6 months after the trauma, 17 cases (31.5%) within 7-12 months, 8 cases (14.8%) within 13-24 months, 2 cases (3.7%) within 25-36 months, and 8 cases (14.8%) within 37-179 months after the TBI. The Kaplan-Meier curves demonstrated that simple partial seizures, surgical treatment, and onset of seizures occurring within 6 months after injury were associated with PTE. <br><br>CONCLUSIONS: The Cox model indicated that, for patients aged >34 years at the time of injury, the PTE risk was 2.55 times greater than for those aged ≤34 years. In addition, simple partial seizures, surgical treatment and onset of seizures occurring within 6 months after injury were significant risk factors for the development of PTE.<p /> <p>Language: en</p>",
language="en",
issn="1176-6328",
doi="10.2147/NDT.S141486",
url="http://dx.doi.org/10.2147/NDT.S141486"
}