@article{ref1,
title="Proserotoninergic agents and depression (author's transl)",
journal="L'Encephale (1974)",
year="1982",
author="Uzan, A.",
volume="8",
number="2",
pages="273-289",
abstract="The proserotoninergic hypothesis of depression has been for a long time founded on biochemical parameters (brain from suicide patients, CSF and plasma from depressed patients) or more recently on measurement of platelets 5-HT uptake or imipramine binding. New specific proserotoninergic agents confirm this hypothesis since indalpine, a specific 5-HT uptake inhibitor, has a neurochemical and pharmacological profile characteristics of proserotoninergic agents and is effectively antidepressant in human. 5-HT uptake inhibition seems an important property because when we compared two isomers one, a 5-HT uptake inhibitor and at the same time 5-HT releaser, and the other only releaser, we observed that the first has experimental properties similar to indalpine whereas the second has not the classical spectrum of a proserotoninergic agent.<p /><p>Language: fr</p>",
language="fr",
issn="0013-7006",
doi="",
url="http://dx.doi.org/"
}