@article{ref1,
title="Prenatal exposure to nonpersistent endocrine disruptors and behavior in boys at 3 and 5 years",
journal="Environmental health perspectives",
year="2017",
author="Philippat, Claire and Nakiwala, Dorothy and Calafat, Antonia M. and Botton, Jérémie and De Agostini, Maria and Heude, Barbara and Slama, Rémy",
volume="125",
number="9",
pages="e097014-e097014",
abstract="BACKGROUND: Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. <br><br>OBJECTIVES: We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. <br><br>METHODS: We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. <br><br>RESULTS: BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. <br><br>CONCLUSIONS: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314.<p /> <p>Language: en</p>",
language="en",
issn="0091-6765",
doi="10.1289/EHP1314",
url="http://dx.doi.org/10.1289/EHP1314"
}