@article{ref1,
title="Identification of genetic interaction with risk factors using a time-to-event model",
journal="International journal of environmental research and public health",
year="2017",
author="de Andrade, Mariza and Armasu, Sebastian M. and McCauley, Bryan M. and Petterson, Tanya M. and Heit, John A.",
volume="14",
number="10",
pages="e14101228-e14101228",
abstract="BACKGROUND: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. <br><br>METHODS: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18-45 years using a case-only design in a cohort of women with VTE. Women with a VTE event after 45 years of age were censored and contributed only follow-up time. <br><br>RESULTS: We identified two intragenic single nucleotide polymorphisms (SNPs) at genome-wide significance in the PURB gene located on chromosome 7, and two additional intragenic SNPs, one in the LINGO2 gene on chromosome 9 and one in RDXP2 on chromosome X. <br><br>CONCLUSIONS: We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum).<p /> <p>Language: en</p>",
language="en",
issn="1661-7827",
doi="10.3390/ijerph14101228",
url="http://dx.doi.org/10.3390/ijerph14101228"
}