@article{ref1,
title="Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan",
journal="Journal of investigative medicine",
year="2018",
author="Chao, Pei-Chun and Chien, Wu-Chien and Chung, Chi-Hsiang and Chu, Ching-Wen and Yeh, Chin-Bin and Huang, San-Yuan and Lu, Ru-Band and Chang, Hsin-An and Kao, Yu-Chen and Yeh, Hui-Wen and Chiang, Wei-Shan and Chou, Yu-Ching and Tzeng, Nian-Sheng",
volume="66",
number="3",
pages="684-692",
abstract="This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000-2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.<br><br>© American Federation for Medical Research (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.<p /> <p>Language: en</p>",
language="en",
issn="1081-5589",
doi="10.1136/jim-2017-000595",
url="http://dx.doi.org/10.1136/jim-2017-000595"
}