@article{ref1,
title="Early-onset tobacco use and suicide-related behavior - a prospective study from adolescence to young adulthood",
journal="Addictive behaviors",
year="2017",
author="Korhonen, Tellervo and Sihvola, Elina and Latvala, Antti and Dick, Danielle M. and Pulkkinen, Lea and Nurnberger, John and Rose, Richard J. and Kaprio, Jaakko",
volume="79",
number="",
pages="32-38",
abstract="BACKGROUND: Developmental relationships between tobacco use and suicide-related behaviors (SRB) remain unclear. Our objective was to investigate the longitudinal associations of tobacco use in adolescence and SRB in adulthood. <br><br>METHODS: Using a prospective design, we examined whether tobacco use in adolescence is associated with SRB (intentional self-injury, suicide ideation) in young adulthood in a population-based sample of 1330 twins (626 males, 704 females). The baseline and follow-up data were collected by professionally administered semi-structured poly-diagnostic interviews at ages 14 and 22, respectively. <br><br>RESULTS: After adjusting for multiple potential confounders, those who reported early-onset of regular tobacco use had a significantly increased risk for intentional self-injury, such as cutting or burning, at age 22 (adjusted odds ratio [AOR] 4.57, 95% CI 1.93-10.8) in comparison to those who had not at all initiated tobacco use. Also, daily cigarette smoking at baseline was associated with future intentional self-injury (AOR 4.45, 95% CI 2.04-9.70). Early-onset tobacco use was associated with suicidal ideation in females (AOR 3.69, 95% CI 1.56-8.72) but not in males. Considering any SRB, baseline daily smokers (AOR 2.13, 95% CI 1.12-4.07) and females with early onset of regular tobacco use (AOR 3.97, 95% CI 1.73-9.13) had an increased likelihood. Within-family analyses among twin pairs discordant for exposure and outcome controlling for familial confounds showed similar, albeit statistically non-significant, associations. <br><br>CONCLUSION: Early-onset tobacco use in adolescence is longitudinally associated with SRB (intentional self-injury and/or suicide ideation) in young adulthood, particularly among females. Further investigation may reveal whether this association has implications for prevention of SRB in adolescence and young adulthood.<br><br>Copyright © 2017. Published by Elsevier Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0306-4603",
doi="10.1016/j.addbeh.2017.12.008",
url="http://dx.doi.org/10.1016/j.addbeh.2017.12.008"
}