@article{ref1,
title="Epigenetic profiles associated with major depression in the human brain",
journal="Psychiatry research",
year="2017",
author="Bustamante, Angela C. and Armstrong, Don L. and Uddin, Monica",
volume="260",
number="",
pages="439-442",
abstract="We conducted an epigenome-wide association study of Major Depressive Disorder (MDD) in brain-derived DNA using two analytic approaches. DNA methylation data (GSE41826) was used in differential methylation (DM) analyses controlling for age, sex, suicide status, and post-mortem interval; and in weighted gene co-methylation network analyses (WGCNA) in probes mapping to transcription start sites. No probes in the DM analysis survived FDR correction. Nominally significant DM probes were enriched in synaptic function-related genes. WGCNA revealed one module correlated with MDD, enriched in genes associated with mitochondrial function. DM and WGCNA both showed enrichment of genes involved in transcription and DNA binding.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2017.12.010",
url="http://dx.doi.org/10.1016/j.psychres.2017.12.010"
}