@article{ref1,
title="Comparative effect of antipsychotics on risk of self-harm among patients with schizophrenia",
journal="Acta psychiatrica Scandinavica",
year="2018",
author="Ma, C-h and Chang, S-S and Tsai, H-j and Gau, S. s-f and Chen, I-m and Liao, S-c and Chien, Y-l and Hsieh, M. H. and Wu, C-s",
volume="137",
number="4",
pages="296-305",
abstract="OBJECTIVE: To investigate the association of different antipsychotic treatments with hospitalization due to self-harm among patients with schizophrenia. <br><br>METHOD: This retrospective cohort study was based on Taiwan's universal health insurance database. Patients aged 15-45 years with a newly diagnosed schizophrenic disorder in 2001-2012 were included. The study outcome was the first hospitalization due to self-harm or undetermined injury after the diagnosis of schizophrenic disorders. The exposure status of antipsychotics was modeled as a time-dependent variable. The analyses were stratified by antipsychotic dosage based on defined daily dose (DDD). <br><br>RESULTS: Among 70 380 patients with a follow-up of 500 355 person-years, 2272 self-harm hospitalization episodes were identified. Compared with none or former use, current use of several second-generation antipsychotics with a dose of one DDD or above, including amisulpride, aripiprazole, clozapine, risperidone, and sulpiride, was associated with decreased risk of self-harm hospitalization, with clozapine showing the strongest effect (adjusted rate ratio = 0.26, 95% confidence interval 0.15-0.47). <br><br>CONCLUSION: The protective effect on self-harm may vary across different antipsychotics. Further studies are needed to replicate the findings.<br><br>© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0001-690X",
doi="10.1111/acps.12857",
url="http://dx.doi.org/10.1111/acps.12857"
}