@article{ref1,
title="The risk of traumatic brain injury occurring among patients with Parkinson'sdisease: a 14-year population-based study",
journal="World neurosurgery",
year="2018",
author="Eric Nyam, Tee-Tau and Ho, Chung-Han and Wang, Yu-Lin and Lim, Sher-Wei and Wang, Jhi-Joung and Chio, Chung-Ching and Kuo, Jinn-Rung and Wang, Che-Chuan",
volume="113",
number=" ",
pages="e328-e335",
abstract="BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson's disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. MATERIAL AND METHODS: The study selected 6,076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan.The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted with the potential confounding factors. <br><br>RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (p=.0007). Patients with PD had a higher risk ofTBI (HR =1.63; 95% confidence interval [CI], 1.32-2.01) compared to the general population.Patients with PD with TBI incidence had a higher Charlson'scomorbidity index score than the general population with TBI outcome (p<.0001). Fall is the major cause of TBI in patients with PD. <br><br>CONCLUSIONS: This study demonstrated that patients with PDhave a highrisk of TBI, andthe major cause of TBI in patients with PD is fall.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1878-8750",
doi="10.1016/j.wneu.2018.02.027",
url="http://dx.doi.org/10.1016/j.wneu.2018.02.027"
}