@article{ref1,
title="Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury",
journal="Arquivos Brasileiros de Oftalmologia",
year="2018",
author="Ilhan, Abdullah and Yolcu, Umit and Oztas, Emin and Erdem, Uzeyir",
volume="81",
number="3",
pages="226-231",
abstract="PURPOSE: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. <br><br>METHODS: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury. The control group received saline only. Thirty minutes after the application of NM, the NM + PAC group received PAC (100 mg/kg) via gastric gavage, while the NM + CoQ10 group received CoQ10 (10 mg/kg) via intraperitoneal injection. PAC and CoQ10 were administered once a day for 5 consecutive days. The rats were then sacrificed. Macroscopic images of the eyes were examined and eye tissues were collected for histology. <br><br>RESULTS: The treatment groups were compared to the control group with regard to both corneal opacity and lid injury scores. The findings were not significantly different for both the NM + PAC and NM + CoQ10 groups. In both the NM + PAC and NM + CoQ10 groups, the histological changes seen in the NM group demonstrated improvement. <br><br>CONCLUSIONS: Our results indicate that PAC and CoQ10 treatments have therapeutic effects on NM-induced ocular injury in a rat model. PAC and CoQ10 may be novel options in patients with NM-induced ocular injury.<p /> <p>Language: en</p>",
language="en",
issn="0004-2749",
doi="10.5935/0004-2749.20180045",
url="http://dx.doi.org/10.5935/0004-2749.20180045"
}