@article{ref1,
title="A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study",
journal="Annals of epidemiology",
year="2018",
author="Ablett, Andrew D. and Wood, Adrian D. and Barr, Rebecca and Guillot, Jordan and Black, Alison J. and Macdonald, Helen M. and Reid, David M. and Myint, Phyo K.",
volume="28",
number="8",
pages="557-562.e2",
abstract="PURPOSE: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. <br><br>METHODS: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997-2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. <br><br>RESULTS: Of 3883 participants, 3293 scored ACB = 0, 328 scored ACB = 1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB = 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals] = 1.81 [1.25-2.62]; P = 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30-7.99]; P = 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. <br><br>CONCLUSIONS: The risk of falling associated with ACB observed in older age may also extend to middle-aged women.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1047-2797",
doi="10.1016/j.annepidem.2018.05.011",
url="http://dx.doi.org/10.1016/j.annepidem.2018.05.011"
}