@article{ref1,
title="Increased serum concentrations of soluble ST2 predict mortality after burn injury",
journal="Clinical chemistry and laboratory medicine",
year="2018",
author="Hacker, Stefan and Dieplinger, Benjamin and Werba, Gregor and Nickl, Stefanie and Roth, Georg A. and Krenn, Claus G. and Mueller, Thomas and Ankersmit, Hendrik J. and Haider, Thomas",
volume="56",
number="12",
pages="2079-2087",
abstract="BACKGROUND: Large burn injuries induce a systemic response in affected patients. Soluble ST2 (sST2) acts as a decoy receptor for interleukin-33 (IL-33) and has immunosuppressive effects. sST2 has been described previously as a prognostic serum marker. Our aim was to evaluate serum concentrations of sST2 and IL-33 after thermal injury and elucidate whether sST2 is associated with mortality in these patients. <br><br>METHODS: We included 32 burn patients (total body surface area [TBSA] >10%) admitted to our burn intensive care unit and compared them to eight healthy probands. Serum concentrations of sST2 and IL-33 were measured serially using an enzyme-linked immunosorbent assay (ELISA) technique. <br><br>RESULTS: The mean TBSA was 32.5%±19.6%. Six patients (18.8%) died during the hospital stay. Serum analyses showed significantly increased concentrations of sST2 and reduced concentrations of IL-33 in burn patients compared to healthy controls. In our study cohort, higher serum concentrations of sST2 were a strong independent predictor of mortality. <br><br>CONCLUSIONS: Burn injuries cause an increment of sST2 serum concentrations with a concomitant reduction of IL-33. Higher concentrations of sST2 are associated with increased in-hospital mortality in burn patients.<p /> <p>Language: en</p>",
language="en",
issn="1434-6621",
doi="10.1515/cclm-2018-0042",
url="http://dx.doi.org/10.1515/cclm-2018-0042"
}