@article{ref1,
title="The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions",
journal="Neuroimage: clinical",
year="2018",
author="Misquitta, Karen and Dadar, Mahsa and Tarazi, Apameh and Hussain, Mohammed W. and Alatwi, Mohammed K. and Ebraheem, Ahmed and Multani, Namita and Khodadadi, Mozhgan and Goswami, Ruma and Wennberg, Richard and Tator, Charles and Green, Robin and Colella, Brenda and Davis, Karen Deborah and Mikulis, David and Grinberg, Mark and Sato, Christine and Rogaeva, Ekaterina and Louis Collins, D. and Tartaglia, Maria Carmela",
volume="19",
number="",
pages="551-558",
abstract="Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concussions may be associated with smaller regional brain volumes, poorer cognitive performance and behavioural symptoms among former professional football players compared to healthy controls. This study included fifty-three retired Canadian Football League players, 25 age- and education-matched healthy controls, and controls from the Cambridge Centre for Aging and Neuroscience database for validation. Volumetric analyses revealed greater hippocampal atrophy than expected for age in former athletes with multiple concussions than controls and smaller left hippocampal volume was associated with poorer verbal memory performance in the former athletes. Deformation-based morphometry confirmed smaller bilateral hippocampal volume that was associated with poorer verbal memory performance in athletes. Repeated concussions may lead to greater regional atrophy than expected for age.<p /> <p>Language: en</p>",
language="en",
issn="2213-1582",
doi="10.1016/j.nicl.2018.05.014",
url="http://dx.doi.org/10.1016/j.nicl.2018.05.014"
}