@article{ref1,
title="Orthostatic hypotension in patients with late-life depression: prevalence and validation of a new screening tool",
journal="International journal of geriatric psychiatry",
year="2018",
author="Shanbhag, Amruta and Awai, Helen and Rej, Soham and Thomas, Alan J. and Puka, Klajdi and Vasudev, Akshya",
volume="33",
number="10",
pages="1397-1402",
abstract="OBJECTIVES: The objective of this study was to assess the prevalence of orthostatic hypotension (OH) in a sample of late life depression (LLD) patients and to determine the validity of a standardized questionnaire, the Orthostatic Hypotension Questionnaire (OHQ). Secondarily, we wished to assess variables associated with OH. <br><br>METHODS: We conducted a cross-sectional study on 82 consecutive geriatric outpatients presenting with LLD. OH was defined as a fall in systolic blood pressure of greater than 20 mm Hg and/or 10 mm Hg on diastolic blood pressure on an orthostatic stress test from sitting to standing. Logistic regressions were used to identify factors associated with OH. <br><br>RESULTS: The prevalence of OH as measured on the orthostatic stress test and on the OHQ was 28% and 57%, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the OHQ were 69.6% (95% CI 47%-87%), 47.5% (95%CI 34%-61%), 0.54 (95% CI: 0.43-0.64), 34% (95%CI 21%-49%), and 80% (95%CI 63%-92%), respectively. Females were more likely to have OH (OR: 3.96, 95%CI 1.06-14.89, P = .041), and those married or in a common-law relationship were less likely to have OH (OR: 0.25, 95% CI 0.08-0.72, P = .011). <br><br>CONCLUSIONS: OH is common in patients with LLD conferring them a risk of gait instability and falls. Females had a higher risk of having OH while participants who were married or in a common-law relationship were less likely to have OH. Although the OHQ is a quick to administer paper-based screening test, it did not show adequate diagnostic accuracy in patients with LLD seen in a routine psychiatry clinic.<br><br>© 2018 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0885-6230",
doi="10.1002/gps.4951",
url="http://dx.doi.org/10.1002/gps.4951"
}