@article{ref1,
title="The minimum clinically important difference (MCID) for a falls intervention in Parkinson's: a Delphi study",
journal="Parkinsonism and related disorders",
year="2019",
author="Henderson, Emily J. and Morgan, Gemma S. and Amin, Jigisha and Gaunt, Daisy M. and Ben-Shlomo, Yoav",
volume="61",
number="",
pages="106-110",
abstract="BACKGROUND: Falls are common in Parkinson's disease so any intervention that reduced falls risk would be of value. One potential intervention is the use of cholinesterase inhibitor (ChEi) drugs. <br><br>OBJECTIVE: To establish the minimum clinically important difference (MCID) for fall rates to inform the effect estimate for sample size calculations of future clinical trials. <br><br>METHODS: We performed a Delphi study assembling a panel of experts in Parkinson's disease from academic and clinical medicine in order to reach a consensus of opinion. Responses from a panel were summarised and resent to the group, until consensus was reached. <br><br>RESULTS: 780 clinicians, who had been caring for people with Parkinson's for an average of 14 years, were contacted via three routes. The median (Interquartile range (IQR)) MCID after round 1 was 25% (IQR 20-30%) which equates to the prevention of 5 (IQR 4-6) falls per year. Increasing consensus after round two confirmed the MCID of 25%, narrowing the (IQ) range to 20%-25%. This was unchanged when the panel were shown the number of participants that would need to be recruited to a clinical trial in order to achieve this difference. <br><br>CONCLUSIONS: We have established that an expert panel of PD specialists consider that an intervention that demonstrated a 25% (IQR 20-25%) relative reduction in falls rate would be clinically meaningful. This estimate can be used to help determine the sample size for any future clinical trial.<br><br>Copyright © 2018. Published by Elsevier Ltd.<p /> <p>Language: en</p>",
language="en",
issn="1353-8020",
doi="10.1016/j.parkreldis.2018.11.008",
url="http://dx.doi.org/10.1016/j.parkreldis.2018.11.008"
}